Recognition of T Cell Epitopes Unique to Cha o 2, the Major Allergen in Japanese Cypress Pollen, in Allergic Patients Cross-Reactive to Japanese Cedar and Japanese Cypress Pollen
نویسندگان
چکیده
منابع مشابه
Recognition of T cell epitopes unique to Cha o 2, the major allergen in Japanese cypress pollen, in allergic patients cross-reactive to Japanese cedar and Japanese cypress pollen.
BACKGROUND Pollens from species of the Cupressaceae family are one of the most important causes of respiratory allergies worldwide. Many patients with pollinosis have specific IgE to both allergens from Japanese cedar and Japanese cypress pollen. We set out to identify T cell epitopes in Cha o 2, the second major allergen of Japanese cypress pollen. METHODS T cell lines (TCL) and T cell clone...
متن کاملAllergic Sensitization to Perennial Allergens in Adults and Children Sensitized to Japanese Cedar or Japanese Cypress Pollen in Japan
In Japan, seasonal allergic rhinitis in the spring due to exposure to Japanese cedar or Japanese cypress pollen is common. However, the allergic profile for perennial allergens in spring pollinosis remains unclear. Therefore, in this study, we investigated the allergic profiles of 652 patients with rhinitis. Total serum IgE, serum-specific IgE, and blood eosinophil counts were measured. Allergi...
متن کاملHistamine antagonist Bepotastine suppresses nasal symptoms caused by Japanese cedar and cypress pollen exposure
Objective: To determine the efficacy of the antihistamine bepotastine on treating nasal symptoms in patients with Japanese cedar and cypress pollinosis, based on two previous studies that looked at bepotastine OD's inhibitory effect on symptom onset after exposure. Design and methods: Randomized double-blind placebo controlled, parallel study. Twenty-eight volunteers with Japanese cedar and cyp...
متن کاملGlycoform analysis of Japanese cedar pollen allergen, Cry j 1.
In our previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 69, 137-144 (2005)), we found that plant complex type N-glycans harboring Lewis a epitope are linked to the mountain cedar pollen allergen Jun a 1. Jun a 1 is a glycoprotein highly homologous with Japanese cedar pollen glycoallergen, Cry j 1. Although it has been found that some plant complex type N-glycans are linked to Cry...
متن کاملDevelopment of experimental allergic rhinitis model using Japanese cedar pollen.
および鼻閉を主症状とする典型的な I型アレルギー疾 患である.くしゃみおよび鼻汁分泌の亢進は,抗ヒス タミン薬により抑制される.一方,患者にとって最も 苦痛を強いられる鼻閉にはグルココルチコイドが繁用 されるが,周知のごとくグルココルチコイドは優れた 効果を発揮するが副作用も強く,これに代わる鼻閉の 治療薬が望まれている.実験動物を用いたヒトの病態 を反映した良好なモデルは,新規治療薬の開発に極め て重要な位置にあることは論をまたない.そこで,我々 はモルモットを用いてスギ花粉抽出エキスで経鼻的に 感作し,以後スギ花粉の反復吸入を行うことにより, ヒトの病態に類似した症状を呈するアレルギー性鼻炎 モデルの開発を企図した.本法により,抗原惹起後に 明らかなくしゃみおよび二相性の鼻閉が認められ,く しゃみの発現は周知のごとく抗ヒスタミン薬で強力に 抑制された.一方,遅発性の鼻閉は,システ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Allergology International
سال: 2009
ISSN: 1323-8930
DOI: 10.2332/allergolint.08-oa-0027